.loading-spinner{--size:88px;--thickness:8px;--speed:1s;--c1:var(--dioscor-blue);--c2:var(--dioscor-purple-bright);width:var(--size);height:var(--size);background:0 0;border-radius:50%;flex:none;position:absolute;top:54px;left:50%;transform:translate(-50%)}.loading-spinner:before{content:"";background:conic-gradient(from 0deg, #02afef00 0deg, var(--c1) 70deg, var(--c2) 300deg, var(--c2) 320deg, transparent 320deg);-webkit-mask:radial-gradient(farthest-side, transparent calc(100% - var(--thickness)), var(--mask-solid) calc(100% - var(--thickness)));mask:radial-gradient(farthest-side, transparent calc(100% - var(--thickness)), var(--mask-solid) calc(100% - var(--thickness)));animation:dioscor-spin var(--speed) linear infinite;will-change:transform;border-radius:50%;position:absolute;inset:0}.loading-progress{--height:9px;--radius:999px;--c1:var(--dioscor-blue);--c2:var(--dioscor-purple-bright);width:535px;height:var(--height);border-radius:var(--radius);background:linear-gradient(90deg, var(--c1), var(--c2));position:absolute;top:280px;left:50%;overflow:hidden;transform:translate(-50%);box-shadow:inset 0 0 0 1px #00000014}.loading-progress:after{content:"";filter:blur(.4px);will-change:left;background:linear-gradient(90deg,#fff0 0%,#ffffffad 48%,#fff0 100%);width:34%;animation:1.45s ease-in-out infinite dioscor-progress-shine;position:absolute;top:-120%;bottom:-120%;left:-38%;transform:skew(-22deg)}@keyframes dioscor-spin{0%{transform:rotate(0)}to{transform:rotate(360deg)}}@keyframes dioscor-progress-shine{0%{left:-38%}to{left:104%}}@supports ((-webkit-mask:radial-gradient(white, black))){.loading-spinner:before{-webkit-mask:radial-gradient(farthest-side, transparent calc(100% - var(--thickness)), var(--mask-solid) calc(100% - var(--thickness)))}}@media (prefers-reduced-motion:reduce){.loading-spinner,.loading-spinner:before,.loading-progress:after{animation:none}.loading-progress:after{opacity:0}}
.snackbar-viewport{z-index:30;pointer-events:none;gap:10px;width:min(720px,100vw - 32px);display:grid;position:fixed;bottom:28px;left:50%;transform:translate(-50%)}.snackbar{--snackbar-tone:var(--dioscor-blue);--snackbar-label:var(--snackbar-info);border:1px solid var(--dioscor-border-soft);border-left:3px solid var(--snackbar-tone);background:var(--surface);min-height:58px;color:var(--dioscor-ink);pointer-events:auto;border-radius:6px;grid-template-columns:44px minmax(0,1fr) auto;align-items:center;display:grid;position:relative;overflow:hidden;box-shadow:0 7px 18px #36486a2e}.snackbar--action{--snackbar-tone:var(--snackbar-action);--snackbar-label:var(--snackbar-action)}.snackbar--error{--snackbar-tone:var(--dioscor-high);--snackbar-label:var(--dioscor-high)}.snackbar--warning{--snackbar-tone:var(--dioscor-moderate);--snackbar-label:var(--dioscor-moderate)}.snackbar--success{--snackbar-tone:var(--dioscor-green);--snackbar-label:var(--dioscor-green)}.snackbar--info{--snackbar-tone:var(--dioscor-blue);--snackbar-label:var(--snackbar-info)}.snackbar-icon{border:2px solid var(--snackbar-tone);width:22px;height:22px;color:var(--snackbar-tone);font-size:var(--type-p2-size);font-weight:var(--font-weight-heavy);border-radius:50%;justify-self:center;place-items:center;line-height:1;display:grid}.snackbar-content{min-width:0;padding:11px 0}.snackbar-title{color:var(--snackbar-label);font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);text-transform:uppercase;margin-bottom:2px;line-height:1.2;display:block}.snackbar-content p{color:var(--text-dark);font-size:var(--type-h4-size);overflow-wrap:anywhere;white-space:normal;margin:0;line-height:1.25}.snackbar-actions{flex-shrink:0;align-items:center;gap:12px;padding:0 14px;display:flex}.snackbar-action{background:var(--dioscor-purple);height:34px;color:var(--on-dark);font-size:var(--type-p2-size);font-weight:var(--font-weight-bold);white-space:nowrap;cursor:pointer;border:0;border-radius:6px;padding:0 14px}.snackbar-action:focus-visible,.snackbar-close:focus-visible{outline:none;box-shadow:0 0 0 3px #02afef3d}.snackbar-close{width:24px;height:24px;color:var(--text-neutral);font-size:var(--type-h2-size);font-weight:var(--font-weight-light);cursor:pointer;background:0 0;border:0;place-items:center;padding:0;line-height:1;display:grid}.snackbar-timer{background:var(--snackbar-tone);height:3px;position:absolute;bottom:0;left:0;right:38px}
.dropdown-indicator{width:var(--dropdown-icon-size);height:var(--dropdown-icon-size);flex:0 0 var(--dropdown-icon-size);background:var(--dropdown-icon) no-repeat center / var(--dropdown-icon-size) var(--dropdown-icon-size);transition:transform .16s;display:block}.app-dropdown{--app-dropdown-width:100%;--app-dropdown-height:42px;--app-dropdown-border:var(--dioscor-ink);--app-dropdown-menu-border:var(--app-dropdown-border);--app-dropdown-bg:var(--dioscor-field);--app-dropdown-color:var(--dioscor-ink);--app-dropdown-value-color:var(--text-muted);--app-dropdown-font-size:var(--type-control-size);--app-dropdown-line-height:1.2;--app-dropdown-padding:7px 8px 7px 18px;--app-dropdown-option-height:42px;--app-dropdown-option-color:var(--text-strong);--app-dropdown-option-font-size:var(--type-control-size);--app-dropdown-menu-top:calc(100% - 1px);width:var(--app-dropdown-width);display:inline-grid;position:relative}.app-dropdown__label{color:var(--app-dropdown-label-color,var(--text-strong));font-size:var(--app-dropdown-label-size,var(--type-h2-size));font-weight:var(--app-dropdown-label-weight,var(--font-weight-medium));line-height:var(--app-dropdown-label-line-height,var(--type-h2-line-height))}.app-dropdown__trigger{width:var(--app-dropdown-width);min-height:var(--app-dropdown-height);border:1px solid var(--app-dropdown-border);background:var(--app-dropdown-bg);color:var(--app-dropdown-color);padding:var(--app-dropdown-padding);font-size:var(--app-dropdown-font-size);line-height:var(--app-dropdown-line-height);cursor:pointer;border-radius:5px;outline:none;justify-content:space-between;align-items:center;display:flex}.app-dropdown__value{min-width:0;color:var(--app-dropdown-value-color);text-overflow:ellipsis;white-space:nowrap;overflow:hidden}.app-dropdown__indicator{color:var(--text-strong)}.app-dropdown--open .app-dropdown__indicator{transform:rotate(180deg)}.app-dropdown__menu{z-index:10;top:var(--app-dropdown-menu-top);width:var(--app-dropdown-width);max-height:var(--app-dropdown-menu-max-height,260px);border:1px solid var(--app-dropdown-menu-border);background:var(--app-dropdown-bg);border-bottom:0;position:absolute;left:0;overflow:auto;box-shadow:0 10px 22px #36486a1f}.app-dropdown__option{width:100%;min-height:var(--app-dropdown-option-height);border:0;border-bottom:1px solid var(--app-dropdown-menu-border);background:var(--app-dropdown-bg);color:var(--app-dropdown-option-color);padding:var(--app-dropdown-option-padding,6px 18px);font-size:var(--app-dropdown-option-font-size);line-height:var(--app-dropdown-line-height);text-align:left;cursor:pointer;display:block}.app-dropdown__option:hover,.app-dropdown__option--active,.app-dropdown__option[aria-selected=true]{background:var(--surface-hover)}.app-dropdown.app-dropdown--auth-title{--app-dropdown-width:100%;--app-dropdown-height:58px;--app-dropdown-border:var(--dioscor-border-strong);--app-dropdown-menu-border:var(--dioscor-border-strong);--app-dropdown-bg:var(--dioscor-field);--app-dropdown-color:var(--dioscor-ink);--app-dropdown-value-color:var(--dioscor-ink);--app-dropdown-option-color:var(--dioscor-ink);--app-dropdown-font-size:var(--type-control-size);--app-dropdown-padding:11px 8px 11px 18px;--app-dropdown-option-height:44px;--app-dropdown-option-font-size:var(--type-control-size)}.app-dropdown.app-dropdown--auth-title .app-dropdown__option:hover,.app-dropdown.app-dropdown--auth-title .app-dropdown__option--active,.app-dropdown.app-dropdown--auth-title .app-dropdown__option[aria-selected=true]{background:var(--surface-hover)}.app-dropdown.app-dropdown--auth-title .dropdown-indicator{filter:none;opacity:1}.result-select{--app-dropdown-width:var(--result-select-width);--app-dropdown-height:var(--result-select-height);--app-dropdown-border:var(--dioscor-border);--app-dropdown-menu-border:var(--dioscor-border);--app-dropdown-bg:var(--dioscor-field);--app-dropdown-font-size:var(--type-p2-size);--app-dropdown-line-height:var(--type-p2-line-height);--app-dropdown-padding:0 8px 0 9px;--app-dropdown-label-color:var(--dioscor-ink);--app-dropdown-label-size:var(--type-p4-size);--app-dropdown-label-weight:var(--font-weight-heavy);--app-dropdown-label-line-height:var(--type-p4-line-height);--app-dropdown-option-height:30px;--app-dropdown-option-font-size:var(--type-p2-size);--app-dropdown-option-padding:6px 9px;gap:6px}.result-select--mechanism{margin-bottom:18px}.result-select--woe{--result-select-width:var(--result-select-wide-width);margin:17px}.app-dropdown--new-compound-route{--app-dropdown-width:100%;--app-dropdown-height:42px;--app-dropdown-border:var(--dioscor-ink);--app-dropdown-menu-border:var(--dioscor-ink);--app-dropdown-bg:var(--dioscor-field);--app-dropdown-font-size:var(--type-control-size);--app-dropdown-padding:8px 8px 8px 18px;--app-dropdown-option-height:42px;--app-dropdown-option-font-size:var(--type-control-size);margin-bottom:31px}
.pdf-export-stage{background:var(--dioscor-page);width:1120px;color:var(--dioscor-ink);pointer-events:none;position:absolute;top:0;left:-100000px;overflow:visible}.pdf-report{background:var(--dioscor-page);width:1120px;color:var(--dioscor-ink);padding:36px}.pdf-report-section{background:var(--dioscor-panel-soft);border-radius:5px;margin:0 0 28px;padding:28px;overflow:visible}.pdf-report-section--segmented{background:0 0;padding:0}.species-matrix-export-section{break-inside:avoid}.species-matrix-export-section h1,.species-matrix-export-section>h2{color:var(--dioscor-ink);font-size:var(--type-h1-size);font-weight:var(--font-weight-bold);line-height:var(--type-h1-line-height);margin:0 0 18px}.species-matrix-export-section>h2{font-size:var(--type-h3-size);font-weight:var(--font-weight-medium);line-height:var(--type-h3-line-height)}.pdf-report .species-matrix-export-section .species-matrix-toolbar{margin-top:0}.pdf-report .species-plot-card--pdf-export{break-inside:avoid;margin-top:0}.pdf-report .confidence-score-plot--pdf-export{gap:10px;padding:20px 42px}.pdf-report .confidence-score-plot--pdf-export .confidence-endpoint-group{break-inside:avoid;min-height:142px;padding:10px 0}.pdf-report .confidence-score-plot--pdf-export .confidence-bars{gap:5px}.pdf-report .confidence-score-plot--pdf-export .confidence-bar-row{min-height:15px}.pdf-report .confidence-score-plot--pdf-export .confidence-bar-half{height:14px}.pdf-report-section:last-child{margin-bottom:0}.pdf-report-cover{grid-template-columns:1fr 320px;gap:24px;display:grid}.pdf-report-header{grid-column:1/-1}.pdf-report-header h1{color:var(--dioscor-ink);font-size:var(--type-h1-size);font-weight:var(--font-weight-bold);line-height:var(--type-h1-line-height);margin:0}.pdf-report-header p{color:var(--dioscor-ink);font-size:var(--type-p2-size);line-height:var(--type-p2-line-height);margin:8px 0 0}.pdf-report-meta{align-content:start;gap:10px;display:grid}.pdf-report-meta span{background:var(--surface-disabled);min-width:0;color:var(--dioscor-ink);font-size:var(--type-p2-size);line-height:var(--type-p2-line-height);overflow-wrap:anywhere;border-radius:5px;padding:8px 10px}.pdf-report-structure{gap:10px;display:grid}.pdf-report-structure h2{color:var(--dioscor-ink);font-size:var(--type-h4-size);font-weight:var(--font-weight-medium);margin:0}.pdf-report-disclaimer{grid-column:1/-1;width:auto;margin:0}.pdf-report .summary-link,.pdf-report .app-dropdown,.pdf-report .mechanism-evidence-link,.pdf-report button{display:none}.pdf-report .species-matrix-screen,.pdf-report .structure-attribution-screen,.pdf-report .mechanism-screen,.pdf-report .woe-screen{min-height:0}.pdf-report .species-table-wrap,.pdf-report .woe-table-wrap,.pdf-report .mechanism-table-wrap{overflow:visible}.pdf-report .mechanism-table,.pdf-report .woe-reference-table{width:100%;min-width:0}.pdf-report .mechanism-scroll-track,.pdf-report .mechanism-scroll-button{display:none}.pdf-report .summary-card-grid,.pdf-report .summary-result-grid,.pdf-report .mechanism-card-grid,.pdf-report .mechanism-pattern-grid{break-inside:avoid}.pdf-report-subsection{margin-top:24px}.pdf-report-subsection:first-of-type{margin-top:0}.pdf-report-subsection h2{color:var(--dioscor-ink);font-size:var(--type-h3-size);font-weight:var(--font-weight-medium);line-height:var(--type-h3-line-height);margin:0 0 12px}
:root{--lightningcss-light:initial;--lightningcss-dark: ;color-scheme:light;--background:#fcfcfc;--foreground:#172033;--muted:#637087;--surface:#fff;--surface-strong:#eff4f8;--border:#d8e0ea;--accent:#176c77;--accent-strong:#0f4c55;--accent-soft:#dff1f2;--critical:#a13d45;--critical-soft:#fde8ea;--focus:#f4b942;--shadow:0 18px 60px #1c2c4a1f;--radius-shell:18px;--radius-panel:12px;--radius-control:8px;--dioscor-ink:#36486a;--dioscor-page:#fcfcfc;--dioscor-panel:#e2e0f0;--dioscor-panel-soft:#f5f4fb;--dioscor-field:#fbf7f5;--dioscor-purple:#7b2d8c;--dioscor-blue:#02afef;--dioscor-green:#00c896;--auth-action-green:#007a66;--dioscor-low:#169f01;--dioscor-moderate:#d07d00;--dioscor-high:#d00000;--dioscor-border:#8c8aa8;--dioscor-border-strong:#5f6f92;--dioscor-border-soft:#cfd6e2;--dioscor-border-row:#d8d8d8;--dioscor-border-chart:#242424;--dioscor-link-teal:#258491;--dioscor-action-blue:#5b5fc8;--dioscor-purple-bright:#8b3aae;--dioscor-violet:#6750a4;--snackbar-info:#376fb4;--snackbar-action:#ef7f1a;--text-strong:#1d1b20;--text-dark:#111827;--text-neutral:#3f3f46;--text-muted:#5e5e5e;--text-danger:#ff0606;--surface-muted:#f0f0f0;--surface-disabled:#e4e4e4;--surface-hover:#eeeaf6;--surface-table-head:#f5f5f5;--surface-table-row:#f7f7f7;--surface-table-row-alt:#f3f3f3;--surface-table-row-even:#fbfbfb;--surface-meter:#dbdbdb;--signal-card-hover:#d4e5fb;--surface-track:#d9d9d9;--surface-scroll-track:#e5e5e5;--surface-divider:#bec2d2;--on-dark:#fff;--on-accent:#f5f4fb;--mask-solid:#000;--status-active-soft:#f7d6d6;--status-inactive-soft:#caf3c5;--status-unavailable-soft:#f6f6f6;--status-warning-soft:#ffe8bf;--status-warning-border:#f0a432;--risk-high-soft:#fcebeb;--risk-moderate-soft:#ffee9d;--risk-low-soft:#e9f9e6;--species-positive-soft:#f5dada;--species-negative-soft:#cff5cb;--confidence-positive-soft:#f0b8b8;--confidence-negative-soft:#bdeeba;--confidence-secondary:#5d5bcf;--confidence-magenta:#e91e85;--confidence-unavailable:#9b9b9b;--critical-border-soft:#e7a6ad;--type-display-size:64px;--type-display-weight:400;--type-display-line-height:1;--type-jumbo-size:110px;--type-hero-size:48px;--type-control-size:20px;--type-action-size:16px;--type-eyebrow-size:.78rem;--type-hidden-size:0;--type-table-head-size:10px;--type-micro-size:9px;--font-weight-light:300;--font-weight-regular:400;--font-weight-medium:500;--font-weight-semibold:600;--font-weight-bold:700;--font-weight-heavy:800;--dropdown-icon-size:24px;--dropdown-icon:url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAACXBIWXMAAAsTAAALEwEAmpwYAAAAAXNSR0IArs4c6QAAAARnQU1BAACxjwv8YQUAAAAOdEVYdFNvZnR3YXJlAEZpZ21hnrGWYwAAAI1JREFUeAHtj9EJhDAQREflejg4DrYULcXKLMVW8mkPEjUDUUQS2ejvPggbssMbAhiGkUUC/5+MnG8ydW7hZwxhtGEmBXzjLmaG4oLGo68AR9e15CQXZpjNeSrcIF+RpcG4hiso+qCLvzvktUfnJuceFaRK9meNXFWQKIFWHrM69hLetfJiWMIDwzCK2ADliEN1x5vx7gAAAABJRU5ErkJggg==);--page-scrollbar-size:14px;--page-scrollbar-track:#f1f3f8;--result-select-width:196px;--result-select-wide-width:260px;--result-select-height:38px;--font-display:"Cal Sans", sans-serif;--font-ui:Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;--type-h1-size:28px;--type-h1-weight:600;--type-h1-line-height:1.2;--type-h2-size:22px;--type-h2-weight:600;--type-h2-line-height:1.25;--type-h3-size:18px;--type-h3-weight:500;--type-h3-line-height:1.35;--type-h4-size:15px;--type-h4-weight:500;--type-h4-line-height:1.4;--type-p1-size:14px;--type-p1-weight:400;--type-p1-line-height:1.5;--type-p2-size:13px;--type-p2-weight:400;--type-p2-line-height:1.5;--type-p3-size:12px;--type-p3-weight:500;--type-p3-line-height:1.4;--type-p4-size:11px;--type-p4-weight:400;--type-p4-line-height:1.4}*{box-sizing:border-box}html{background:var(--dioscor-page);scrollbar-color:var(--dioscor-purple-bright) var(--page-scrollbar-track);scrollbar-width:thin;min-height:100%}.not-found-screen{color:#f8fbff;min-height:100vh;font-family:var(--font-ui);background:linear-gradient(#030e1b1a 0%,#030e1bbd 72%),linear-gradient(90deg,#030a1475 0%,#030d1b0f 50%,#030a147a 100%),url(/figma/dioscor-404-background.png) 50%/cover no-repeat,#03101f;place-items:center;padding:clamp(32px,6vw,88px) 24px;display:grid;position:relative;overflow:hidden}.not-found-screen:before{content:"";pointer-events:none;background:radial-gradient(circle at 50% 38%,#00d4cd24,#0000 28%),radial-gradient(circle at 50% 86%,#010812b8,#0000 36%);position:absolute;inset:0}.not-found-content{z-index:1;text-align:center;flex-direction:column;align-items:center;width:min(100%,712px);padding-top:clamp(12px,3vh,40px);display:flex;position:relative}.not-found-code{font-family:var(--font-display);letter-spacing:0;color:#15c7ce17;-webkit-text-stroke:clamp(1px, .12vw, 2px) #58ebf185;text-shadow:0 0 38px #09e2e029,0 28px 80px #00000061;margin:0;font-size:clamp(116px,19vw,250px);font-weight:400;line-height:.82}.not-found-signal{color:#36f3ef;text-transform:uppercase;grid-template-columns:1fr auto 1fr;align-items:center;gap:24px;width:min(100%,420px);margin-top:clamp(30px,4vw,48px);display:grid}.not-found-signal span{background:linear-gradient(90deg,#0000,#d0e2efb8);height:1px}.not-found-signal span:last-child{background:linear-gradient(90deg,#d0e2efb8,#0000)}.not-found-signal strong{letter-spacing:.3em;white-space:nowrap;align-items:center;gap:18px;font-size:clamp(.76rem,1.2vw,1rem);font-weight:500;display:inline-flex;position:relative}.not-found-signal strong:before{content:"";background:#30d6d1;border-radius:999px;width:12px;height:12px;box-shadow:0 0 18px #30d6d1b3}.not-found-content h1{font-family:var(--font-display);letter-spacing:0;text-shadow:0 8px 36px #0000006b;margin:clamp(30px,4vw,46px) 0 0;font-size:clamp(3.1rem,6vw,5.25rem);font-weight:400;line-height:1}.not-found-copy{color:#eef4fce0;max-width:620px;margin:24px 0 0;font-size:clamp(1rem,1.55vw,1.24rem);line-height:1.45}.not-found-primary{color:#fff;background:linear-gradient(#2fd0c1 0%,#21b5a8 100%);border:1px solid #42edda70;border-radius:7px;justify-content:center;align-items:center;width:min(100%,712px);min-height:70px;margin-top:clamp(42px,5vw,60px);font-size:clamp(1.12rem,2vw,1.62rem);font-weight:700;text-decoration:none;transition:background .16s,transform .16s,box-shadow .16s;display:inline-flex;box-shadow:0 20px 54px #00000047,inset 0 1px #ffffff2e}.not-found-primary:hover{background:linear-gradient(#38ded0 0%,#22bdae 100%);transform:translateY(-1px);box-shadow:0 24px 64px #00000057,0 0 42px #2fd0c129}.not-found-primary:focus-visible{outline:3px solid var(--focus);outline-offset:5px}body{background:var(--dioscor-page);min-height:100%;color:var(--foreground);font-family:var(--font-ui);letter-spacing:0;margin:0}::-webkit-scrollbar{width:var(--page-scrollbar-size);height:var(--page-scrollbar-size)}::-webkit-scrollbar-track{background:linear-gradient(var(--dioscor-page), var(--dioscor-page)) padding-box, linear-gradient(180deg, #02afef33, #8b3aae33) border-box;border:3px solid #0000;border-radius:999px}::-webkit-scrollbar-thumb{border:3px solid var(--dioscor-page);background:linear-gradient(180deg, var(--dioscor-blue), var(--dioscor-purple-bright)) padding-box;border-radius:999px;box-shadow:0 0 0 1px #36486a1a}::-webkit-scrollbar-thumb:hover{background:linear-gradient(180deg, var(--dioscor-blue) 0%, var(--dioscor-purple) 100%) padding-box}.sr-only{clip:rect(0 0 0 0);white-space:nowrap;border:0;width:1px;height:1px;margin:-1px;padding:0;position:absolute;overflow:hidden}button,input,select,textarea{font:inherit}.skip-link{z-index:20;border-radius:var(--radius-control);background:var(--foreground);color:var(--on-dark);padding:10px 14px;text-decoration:none;position:fixed;top:12px;left:12px;transform:translateY(-160%)}.skip-link:focus{transform:translateY(0)}.dioscor-app{background:var(--dioscor-page);min-height:100vh;color:var(--dioscor-ink);overflow-x:hidden}@supports (overflow:clip){.dioscor-app{overflow:clip visible}}.auth-screen{min-height:max(100vh,760px);color:var(--dioscor-ink);background:linear-gradient(90deg,#fcfcfcad,#f5f4fb8a 48%,#fcfcfcb3),url(/figma/auth-passwordless-background.png) 50%/cover no-repeat;place-items:center;padding:96px 24px 72px;display:grid;position:relative}.auth-screen--login{padding-bottom:96px}.auth-screen--createAccount{padding-bottom:64px}.auth-screen--checkEmail{padding-bottom:96px}.auth-panel{background:#f5f4fbf5;border:1px solid #5f6f923d;border-radius:10px;width:min(660px,100vw - 40px);padding:76px 64px 62px;position:relative;box-shadow:0 28px 90px #36486a2e}.auth-panel:before{background:linear-gradient(90deg, var(--dioscor-blue), var(--dioscor-purple-bright));content:"";border-radius:10px 10px 0 0;height:6px;position:absolute;top:0;left:0;right:0}.auth-screen--login .auth-panel{min-height:660px}.auth-screen--createAccount .auth-panel{width:min(760px,100vw - 40px);min-height:812px}.auth-screen--checkEmail .auth-panel{min-height:668px}.auth-brand{justify-items:center;display:grid}.auth-brand h1{color:var(--dioscor-ink);font-family:var(--font-display);font-size:var(--type-display-size);font-weight:var(--font-weight-regular);letter-spacing:0;margin:0;line-height:1}.auth-powered-by{object-fit:contain;width:184px;height:21px;margin-top:12px;display:block}.auth-form{grid-template-columns:repeat(2,minmax(0,1fr));column-gap:30px;width:100%;display:grid}.auth-form--login{row-gap:26px;margin-top:70px}.auth-form--create{row-gap:26px;margin-top:54px}.auth-form-heading{grid-column:1/-1;gap:12px;display:grid}.auth-form-heading h2{color:var(--dioscor-ink);font-size:38px;font-weight:var(--font-weight-bold);margin:0;line-height:1.1}.auth-form-heading p{max-width:52ch;color:var(--text-neutral);font-size:var(--type-action-size);margin:0;line-height:1.5}.auth-form-heading strong{color:var(--dioscor-ink)}.auth-steps{grid-column:1/-1;align-items:center;gap:18px;margin-bottom:10px;display:flex}.auth-step{color:var(--text-muted);font-size:var(--type-control-size);font-weight:var(--font-weight-semibold);white-space:nowrap;align-items:center;gap:14px;line-height:1;display:flex}.auth-step--active{color:var(--dioscor-ink)}.auth-step-index{border:2px solid var(--dioscor-border-soft);width:48px;height:48px;color:var(--text-muted);font-size:var(--type-control-size);font-weight:var(--font-weight-medium);border-radius:999px;flex:0 0 48px;place-items:center;display:inline-grid}.auth-step--active .auth-step-index{border-color:var(--dioscor-green);color:var(--dioscor-ink);box-shadow:0 0 0 1px #14d2bc29}.auth-step-connector{background:var(--surface-divider);flex:auto;height:1px}.auth-field{color:var(--dioscor-ink);font-size:var(--type-action-size);font-weight:var(--font-weight-medium);gap:10px;line-height:1.2;display:grid}.auth-field--full,.auth-submit{grid-column:1/-1}.auth-field--title{grid-column:1/-1;width:100%}.auth-field input{border:1px solid var(--dioscor-border-strong);background:var(--dioscor-field);width:100%;height:58px;color:var(--dioscor-ink);font-size:var(--type-control-size);border-radius:5px;outline:none;padding:11px 18px;line-height:1.2}.auth-field input::placeholder{color:var(--text-muted);opacity:1}.auth-submit{background:var(--dioscor-purple);width:100%;height:62px;color:var(--on-accent);font-size:var(--type-control-size);font-weight:var(--font-weight-bold);cursor:pointer;border:0;border-radius:5px;justify-content:center;align-items:center;gap:14px;line-height:1;display:inline-flex}.auth-submit-icon{flex:0 0 24px;width:24px;height:24px}.auth-submit:disabled{cursor:not-allowed;opacity:.68}.auth-helper,.auth-account-switch,.auth-new-account,.auth-expiry-note{color:var(--text-neutral);font-size:var(--type-action-size);grid-column:1/-1;margin:0;line-height:1.5}.auth-helper{text-align:center}.auth-account-switch,.auth-new-account{text-align:center;grid-template-columns:1fr auto 1fr;place-items:center;gap:14px 20px;margin-top:26px;display:grid}.auth-account-switch:before,.auth-account-switch:after,.auth-new-account:before,.auth-new-account:after{background:var(--surface-divider);content:"";width:100%;height:1px}.auth-account-switch:before,.auth-new-account:before{grid-area:1/1}.auth-account-switch span,.auth-new-account span{grid-area:1/2}.auth-account-switch:after,.auth-new-account:after{grid-area:1/3}.auth-account-switch button,.auth-new-account button{grid-area:2/1/auto/-1}.auth-account-switch button,.auth-new-account button,.auth-link-button{color:var(--dioscor-purple);cursor:pointer;font:inherit;font-weight:var(--font-weight-bold);text-underline-offset:3px;background:0 0;border:0;text-decoration:underline}.auth-check-email{text-align:center;justify-items:center;gap:28px;width:100%;margin-top:58px;display:grid}.auth-email-row{background:var(--dioscor-field);width:min(100%,520px);min-height:78px;color:var(--dioscor-ink);font-size:var(--type-control-size);text-align:left;border:1px solid #5f6f9247;border-radius:8px;align-items:center;gap:18px;padding:16px 24px;display:flex}.auth-email-row span{border:1px solid var(--dioscor-green);width:48px;height:48px;color:var(--dioscor-green);border-radius:999px;flex:0 0 48px;place-items:center;line-height:1;display:grid}.auth-email-row-icon{width:20px;height:20px;display:block}.auth-submit--wide{width:min(100%,520px)}.auth-link-button{font-size:var(--type-action-size)}.auth-expiry-note{color:var(--text-muted);text-align:center}.app-dropdown--auth-title{--app-dropdown-width:100%;--app-dropdown-height:58px;--app-dropdown-border:var(--dioscor-border-strong);--app-dropdown-menu-border:var(--dioscor-border-strong);--app-dropdown-bg:var(--dioscor-field);--app-dropdown-color:var(--dioscor-ink);--app-dropdown-value-color:var(--dioscor-ink);--app-dropdown-option-color:var(--dioscor-ink);--app-dropdown-font-size:var(--type-control-size);--app-dropdown-padding:11px 8px 11px 18px;--app-dropdown-option-height:44px;--app-dropdown-option-font-size:var(--type-control-size)}.app-dropdown--auth-title .app-dropdown__indicator{color:var(--dioscor-ink)}.app-dropdown--auth-title .app-dropdown__option:hover,.app-dropdown--auth-title .app-dropdown__option--active,.app-dropdown--auth-title .app-dropdown__option[aria-selected=true]{background:var(--surface-hover)}.dioscor-screen{background:var(--dioscor-page);width:min(100%,1440px);min-height:1024px;margin:0 auto;position:relative}.dioscor-screen--summary{min-height:1024px}.dioscor-header{height:97px;position:absolute;top:34px;left:46px;right:48px}.brand-lockup{align-items:center;gap:20px;display:flex;transform:translateY(10px)}.brand-lockup h1{color:var(--dioscor-ink);font-family:var(--font-display);font-size:var(--type-display-size);font-weight:var(--font-weight-regular);letter-spacing:0;margin:0;font-style:normal;line-height:1}.powered-by-lockup{object-fit:contain;object-position:left center;width:315px;height:36px;margin-top:18px;display:block}.brand-divider{background:linear-gradient(90deg, var(--dioscor-blue), var(--dioscor-purple));height:6px;position:absolute;bottom:0;left:2px;right:0}.header-logout{background:var(--auth-action-green);min-width:92px;height:42px;color:var(--on-dark);font-size:var(--type-action-size);font-weight:var(--font-weight-semibold);cursor:pointer;border:0;border-radius:5px;justify-content:center;align-items:center;line-height:1;display:inline-flex;position:absolute;top:26px;right:0}.disclaimer-banner{background:var(--surface-disabled);border-radius:10px;align-items:center;gap:22px;width:660px;min-height:77px;padding:14px 58px 14px 21px;display:flex;position:absolute;top:205px;left:50%;transform:translate(-50%)}.disclaimer-banner p{color:var(--dioscor-ink);font-size:var(--type-control-size);margin:0;line-height:1.2}.disclaimer-icon{object-fit:contain;flex:0 0 48px;width:48px;height:48px;display:block}.entry-card,.loading-card{background:var(--dioscor-panel);border-radius:10px;width:660px;height:384px;position:absolute;top:332px;left:50%;transform:translate(-50%)}.entry-form{gap:0;width:480px;display:grid;position:absolute;top:45px;left:90px}.entry-label{color:var(--dioscor-ink);font-size:var(--type-h2-size);font-weight:var(--font-weight-medium);line-height:1.23}.entry-input{border:1px solid var(--dioscor-ink);background:var(--dioscor-field);width:480px;height:42px;color:var(--dioscor-ink);font-size:var(--type-control-size);border-radius:5px;outline:none;margin-top:12px;padding:8px 18px;line-height:1.2}.entry-input::placeholder,.app-dropdown--entry-route .app-dropdown__value{color:var(--text-muted)}.entry-input:focus,.auth-field input:focus,.auth-account-switch button:focus-visible,.auth-link-button:focus-visible,.summary-meta input:focus-visible,.app-dropdown__trigger:focus-visible,.entry-submit:focus-visible,.auth-submit:focus-visible,.summary-new:focus-visible,.summary-export:focus-visible,.summary-logout:focus-visible,.header-logout:focus-visible,.logout-confirmation button:focus-visible{outline:none;box-shadow:0 0 0 3px #02afef3d}.entry-route-field{gap:16px;margin-top:30px;display:grid}.app-dropdown--entry-route{--app-dropdown-width:480px;--app-dropdown-height:42px;--app-dropdown-border:var(--dioscor-ink);--app-dropdown-menu-border:var(--dioscor-border-strong);--app-dropdown-bg:var(--dioscor-field);--app-dropdown-font-size:var(--type-control-size);--app-dropdown-padding:7px 8px 7px 18px;--app-dropdown-option-height:42px;--app-dropdown-option-font-size:var(--type-control-size)}.entry-submit{background:var(--dioscor-purple);width:138px;height:42px;color:var(--on-accent);font-family:var(--font-ui);font-size:var(--type-action-size);font-weight:var(--font-weight-semibold);letter-spacing:0;cursor:pointer;border:0;border-radius:5px;justify-content:center;align-items:center;margin-top:42px;font-style:normal;line-height:1;display:inline-flex}.entry-submit:disabled{cursor:not-allowed;opacity:1}.loading-card{align-content:start;justify-items:center;display:grid;position:relative}.loading-card h2{color:var(--dioscor-ink);font-size:var(--type-h2-size);font-weight:var(--font-weight-medium);margin:188px 0 0}.summary-screen{position:absolute;inset:0}.summary-top-actions{gap:20px;display:flex;position:absolute;top:58px;right:48px}.summary-logout,.summary-new,.summary-export{height:42px;color:var(--on-accent);font-size:var(--type-action-size);font-weight:var(--font-weight-bold);border:0;border-radius:5px}.summary-logout{background:var(--dioscor-green);cursor:pointer;width:138px}.summary-new{background:var(--dioscor-action-blue);cursor:pointer;width:186px}.summary-export{background:var(--dioscor-purple);grid-column:9;align-self:end;width:138px}.summary-export:disabled{cursor:not-allowed;opacity:1}.summary-export{cursor:pointer}.summary-meta-row{grid-template-columns:minmax(180px,204px) minmax(132px,164px) repeat(4,minmax(88px,max-content)) minmax(286px,max-content) minmax(0,1fr) 138px;align-items:end;gap:18px;display:grid;position:absolute;top:168px;left:48px;right:48px}.summary-meta{gap:8px;display:grid}.summary-meta span{color:var(--text-strong);font-size:var(--type-p1-size);font-weight:var(--font-weight-medium)}.summary-meta input,.metric-pill{height:31px;color:var(--dioscor-ink);font-size:var(--type-p2-size);border-radius:5px;align-items:center;line-height:1.2;display:flex}.summary-meta input{border:1px solid var(--dioscor-ink);background:var(--dioscor-page);text-overflow:ellipsis;white-space:nowrap;cursor:text;padding:0 9px;position:relative}.summary-meta--overflowing input{padding-right:18px}.summary-meta input::selection{background:#02afef33}.metric-pill{background:var(--surface-disabled);white-space:nowrap;justify-content:center;align-self:end;gap:8px;min-width:0;padding:0 10px}.metric-pill--wide{justify-content:flex-start}.metric-pill span,.metric-pill__value{text-overflow:ellipsis;flex:0 auto;min-width:0;overflow:hidden}.metric-pill__value{font-weight:var(--font-weight-bold)}.metric-pill__value--success{color:var(--dioscor-low)}.metric-pill__value--warning{color:var(--dioscor-moderate)}.metric-pill__value--danger{color:var(--dioscor-high)}.summary-divider{background:var(--surface-divider);height:1px;position:absolute;top:255px;left:48px;right:48px}.summary-sidebar{width:318px;padding-bottom:56px;position:absolute;top:278px;left:48px}.structure-card{background:var(--dioscor-field);border-radius:5px;height:237px;padding:11px 25px 25px}.structure-card h2,.summary-disclosure h2{color:var(--text-strong);font-size:var(--type-p1-size);font-weight:var(--font-weight-medium);margin:0}.structure-preview{border:1px solid var(--dioscor-ink);background:var(--dioscor-page);justify-content:center;align-items:center;height:172px;margin-top:12px;display:flex}.structure-preview__image{object-fit:contain;width:auto;max-width:100%;height:auto;max-height:100%}.structure-preview span{color:var(--text-danger);font-size:var(--type-p4-size)}.summary-disclosure{background:var(--dioscor-field);border-radius:5px;margin-top:30px}.summary-disclosure header{min-height:55px;padding:0}.summary-disclosure-trigger{width:100%;min-height:55px;color:var(--text-strong);font:inherit;text-align:left;cursor:pointer;background:0 0;border:0;justify-content:space-between;align-items:center;padding:0 20px;display:flex}.summary-disclosure-trigger:focus-visible{outline:none;box-shadow:inset 0 0 0 3px #02afef3d}.summary-disclosure--expanded .summary-disclosure-chevron{transform:rotate(180deg)}.summary-disclosure-content{color:var(--dioscor-ink);font-size:var(--type-p4-size);line-height:var(--type-p4-line-height);justify-items:stretch;padding:0 20px 24px;display:grid}.summary-disclosure-content p{width:100%;margin:0}.how-to-read-panel{gap:14px;display:grid}.how-to-read-section{gap:5px;display:grid}.how-to-read-section h3{color:var(--dioscor-ink);font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);line-height:var(--type-p4-line-height);text-transform:uppercase;margin:0}.how-to-read-section p{color:var(--dioscor-ink)}.how-to-diagram{border:1px solid var(--dioscor-border);background:var(--surface);border-radius:5px;gap:12px;margin:2px 0 4px;padding:14px 18px 15px;display:grid}.how-to-diagram figcaption{color:var(--dioscor-ink);font-size:var(--type-p3-size);font-weight:var(--font-weight-heavy);line-height:var(--type-p3-line-height);text-align:center;margin:0}.how-to-diagram__rows{gap:8px;display:grid}.how-to-diagram__row{grid-template-columns:66px minmax(0,1fr);align-items:center;gap:9px;display:grid}.how-to-diagram__row>span{color:var(--dioscor-ink);font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);line-height:1}.how-to-diagram__track{background:var(--surface-meter);border-radius:999px;height:6px;overflow:hidden}.how-to-diagram__bar{border-radius:inherit;height:100%;display:block}.how-to-diagram__bar--tox-low{background:var(--dioscor-low)}.how-to-diagram__bar--tox-moderate{background:var(--dioscor-moderate)}.how-to-diagram__bar--tox-high{background:var(--dioscor-high)}.how-to-diagram__bar--band-cyan{background:var(--dioscor-blue)}.how-to-diagram__bar--band-blue{background:var(--dioscor-action-blue)}.how-to-diagram__bar--band-purple{background:var(--dioscor-purple-bright)}.how-to-diagram__bar--band-magenta{background:var(--confidence-magenta)}.how-to-diagram__bar--band-teal{background:var(--dioscor-link-teal)}.under-development-list{color:var(--dioscor-ink);font-size:var(--type-p4-size);line-height:var(--type-p4-line-height);gap:12px;margin:0;padding:4px 0 0;list-style:none;display:grid}.summary-disclaimer-card{background:var(--dioscor-page);color:var(--dioscor-ink);font-size:var(--type-p1-size);border-radius:5px;margin:12px 0;padding:20px 20px 23px;line-height:1.12}.summary-disclaimer-card p{margin:0 0 15px}.summary-disclaimer-card p:last-child{margin-bottom:0}.summary-panel{--summary-panel-left-offset:413px;background:var(--dioscor-panel-soft);border-radius:5px;width:979px;min-height:0;padding:76px 28px 32px;position:absolute;top:278px;left:413px}.summary-panel:after{content:"";background:var(--dioscor-page);pointer-events:none;height:24px;position:absolute;top:100%;left:0;right:0}.summary-tabs{background:var(--dioscor-page);border-radius:5px 5px 0 0;align-items:flex-start;width:100%;height:37px;display:flex;position:absolute;top:0;left:0}.summary-tab{background:var(--dioscor-page);height:37px;color:var(--dioscor-ink);font-size:var(--type-h4-size);font-weight:var(--font-weight-medium);white-space:nowrap;cursor:pointer;border:0;padding:8px 15px 0;font-family:inherit}.summary-tab--active{background:var(--dioscor-panel-soft);font-weight:var(--font-weight-bold);border-radius:5px 5px 0 0}.summary-tab:focus-visible,.species-subtab:focus-visible{outline:none;box-shadow:inset 0 0 0 3px #02afef3d}.summary-panel h1{color:var(--dioscor-ink);font-size:var(--type-h1-size);font-weight:var(--font-weight-bold);margin:0 0 30px}.summary-card-grid{grid-template-columns:1fr 1fr;gap:20px;display:grid}.summary-card,.summary-result-section{border:1px solid var(--dioscor-border);background:var(--dioscor-page);border-radius:5px;overflow:hidden;box-shadow:0 2px 4px #00000040}.summary-card{min-height:181px}.summary-card header,.summary-result-section>header{background:var(--surface-muted);align-items:center;gap:20px;min-height:30px;padding:0 17px;display:flex}.summary-card h2,.summary-result-section h2{color:var(--dioscor-ink);font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);margin:0}.risk-summary-row{align-items:flex-start;gap:16px;padding:18px 24px 0;display:flex}.risk-badge{min-width:112px;height:44px;font-size:var(--type-p1-size);font-weight:var(--font-weight-semibold);border-radius:5px;justify-content:center;align-items:center;display:inline-flex}.risk-badge--high,.biomarker-chip--high{border:1px solid var(--dioscor-high);background:var(--risk-high-soft);color:var(--dioscor-high)}.risk-badge--moderate,.biomarker-chip--moderate{border:1px solid var(--status-warning-border);background:var(--risk-moderate-soft);color:#000000e0}.risk-badge--low,.biomarker-chip--low{border:1px solid var(--dioscor-low);background:var(--risk-low-soft);color:var(--dioscor-low)}.risk-badge--unavailable,.biomarker-chip--unavailable{border:1px solid var(--dioscor-border);background:var(--status-unavailable-soft);color:var(--text-muted)}.known-molecule{border:1px solid var(--dioscor-border);background:var(--dioscor-field);max-width:266px;min-height:44px;color:var(--dioscor-green);font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);border-radius:5px;align-content:center;gap:4px;padding:6px 10px;display:inline-grid}.summary-link{color:var(--dioscor-blue);font:inherit;font-size:var(--type-p4-size);font-weight:var(--font-weight-medium);text-align:left;cursor:pointer;background:0 0;border:0;align-items:center;gap:6px;padding:0;line-height:1.1;display:inline-flex}.summary-link:focus-visible{border-radius:3px;outline:none;box-shadow:0 0 0 3px #02afef3d}.summary-mini-label{font-size:var(--type-p4-size);font-weight:var(--font-weight-medium);margin:18px 24px 8px}.biomarker-row{flex-wrap:wrap;gap:10px;margin:0 24px;display:flex}.summary-link--species{margin:14px 24px 18px}.biomarker-chip{min-height:20px;font-size:var(--type-p4-size);font-weight:var(--font-weight-bold);border-radius:10px;align-items:center;gap:6px;padding:2px 8px;display:inline-flex}.biomarker-chip small{font-size:var(--type-table-head-size);font-weight:var(--font-weight-bold);line-height:1}.summary-card--confidence{text-align:center}.summary-card--confidence strong{color:var(--dioscor-ink);font-size:var(--type-h1-size);margin-top:28px;line-height:1;display:block}.confidence-meter,.signal-meter{background:var(--surface-meter);border-radius:5px;overflow:hidden}.confidence-meter{width:262px;height:6px;margin:16px auto 0}.confidence-meter span{background:linear-gradient(90deg, var(--dioscor-blue), var(--dioscor-purple-bright));border-radius:5px;height:100%;display:block}.confidence-label{color:var(--dioscor-ink);font-size:var(--type-p1-size);font-weight:var(--font-weight-heavy);margin:10px 0 0}.summary-note{color:var(--text-muted);font-size:var(--type-p4-size);margin:14px 0 0}.summary-result-section{margin-top:25px;padding-bottom:25px}.summary-result-section>header p{color:var(--dioscor-ink);font-size:var(--type-p4-size);font-weight:var(--font-weight-medium);margin:0}.summary-result-grid{grid-template-columns:repeat(4,minmax(0,1fr));gap:20px;padding:28px 25px 0;display:grid}.species-matrix-screen{color:var(--dioscor-ink);padding-bottom:0}.species-matrix-toolbar{justify-content:space-between;align-items:end;gap:20px;margin:35px 0 0;display:flex}.species-subtabs{align-items:flex-end;padding-left:28px;display:flex}.species-subtab{min-width:116px;height:38px;color:var(--dioscor-ink);font:inherit;font-size:var(--type-p2-size);font-weight:var(--font-weight-medium);cursor:pointer;background:0 0;border:0;border-radius:5px 5px 0 0;padding:0 17px}.species-subtab--active{background:var(--surface);font-weight:var(--font-weight-heavy)}.toxicity-key{font-size:var(--type-table-head-size);font-weight:var(--font-weight-heavy);align-items:center;gap:8px;margin-bottom:13px;display:flex}.toxicity-key__pos,.toxicity-key__neg{border-radius:3px;padding:4px 8px}.toxicity-key__pos{background:var(--status-active-soft);color:var(--dioscor-high)}.toxicity-key__neg{background:var(--status-inactive-soft);color:var(--dioscor-low)}.species-table-wrap{background:var(--surface);border-radius:5px;padding:31px 25px 36px;overflow-x:auto}.species-matrix-table{border-collapse:collapse;width:100%;min-width:825px;color:var(--dioscor-ink);font-size:var(--type-p3-size)}.species-matrix-table th,.species-matrix-table td{border:1px solid var(--dioscor-ink);text-align:center;vertical-align:middle;height:34px;padding:5px 10px}.species-matrix-table thead th{height:29px;color:var(--dioscor-ink);font-size:var(--type-p3-size);font-weight:var(--font-weight-heavy);border-top:0;border-left:0;border-right:0}.species-matrix-table tbody th{width:108px;font-weight:var(--font-weight-medium);text-align:left}.species-matrix-cell--positive{background:var(--species-positive-soft);color:var(--dioscor-high)}.species-matrix-cell--negative{background:var(--species-negative-soft);color:var(--dioscor-low)}.species-matrix-cell--unavailable{background:var(--surface-table-row);color:var(--text-muted)}.species-matrix-cell--confidence{background:var(--surface-table-row);color:var(--dioscor-ink)}.matrix-other{background:var(--surface-table-row);min-width:150px;color:var(--dioscor-ink);font-weight:var(--font-weight-medium)}.matrix-other--found{color:var(--dioscor-high);font-weight:var(--font-weight-heavy)}.species-confidence-cell{text-align:left;grid-template-columns:auto auto;justify-content:stretch;align-items:center;gap:3px 7px;display:grid}.species-confidence-cell strong,.species-confidence-status--positive,.species-confidence-status--negative{font-size:var(--type-table-head-size);font-weight:var(--font-weight-heavy);line-height:1}.species-confidence-status--positive{color:var(--dioscor-high)}.species-confidence-status--negative{color:var(--dioscor-low)}.species-confidence-status--unavailable{color:var(--text-muted)}.species-confidence-cell strong{color:var(--confidence-color,var(--dioscor-link-teal));justify-self:end}.species-confidence-track{background:var(--surface-track);border-radius:999px;grid-column:1/-1;height:4px;overflow:hidden}.species-confidence-track span{border-radius:inherit;height:100%;display:block}.species-confidence-bar{background:var(--confidence-color,var(--dioscor-link-teal))}.species-plot-card{border:1px solid var(--dioscor-border);background:var(--dioscor-page);border-radius:5px;margin-top:25px;overflow:hidden;box-shadow:0 2px 4px #00000040}.species-plot-card>header{background:var(--surface-muted);align-items:center;min-height:30px;padding:0 17px;display:flex}.species-plot-card h2{color:var(--dioscor-ink);font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);margin:0}.confidence-score-plot{gap:14px;padding:24px 50px;display:grid}.confidence-axis-headings{color:var(--dioscor-ink);font-size:var(--type-p1-size);font-weight:var(--font-weight-medium);grid-template-columns:1fr 1fr;margin:0 42px -5px;display:grid}.confidence-axis-headings span:first-child{text-align:center;padding-right:28px}.confidence-axis-headings span:last-child{text-align:center;padding-left:28px}.confidence-endpoint-group{border:1px solid var(--dioscor-border-chart);grid-template-columns:42px minmax(0,1fr) 42px;min-height:170px;padding:14px 0;display:grid;position:relative}.confidence-endpoint-label{color:var(--dioscor-ink);font-size:var(--type-p2-size);font-weight:var(--font-weight-medium);writing-mode:vertical-rl;place-items:center;display:grid}.confidence-axis{background:var(--dioscor-ink);width:2px;position:absolute;top:-15px;bottom:-15px;left:50%}.confidence-bars{align-content:center;gap:7px;padding:0 18px;display:grid;position:relative}.confidence-bar-row{grid-template-columns:minmax(0,1fr) minmax(0,1fr);align-items:center;min-height:18px;display:grid}.confidence-bar-half{align-items:center;min-width:0;height:16px;display:flex}.confidence-bar-half--left{justify-content:flex-end}.confidence-bar-half--right{justify-content:flex-start}.confidence-bar{opacity:.75;align-items:center;height:100%;display:flex}.confidence-bar--positive{background:var(--confidence-positive-soft);justify-content:flex-start}.confidence-bar--negative{background:var(--confidence-negative-soft);justify-content:flex-end}.confidence-animal-label{color:var(--dioscor-ink);font-size:var(--type-p3-size);text-overflow:ellipsis;white-space:nowrap;overflow:hidden}.confidence-bar--positive .confidence-animal-label{padding-left:12px}.confidence-bar--negative .confidence-animal-label{padding-right:12px}.confidence-percent{color:var(--confidence-color,var(--confidence-unavailable));font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);flex:none}.confidence-percent--left{margin-right:10px}.confidence-percent--right{margin-left:10px}.confidence-bar-row--unavailable .confidence-percent{color:var(--text-muted)}.ld50-plot{object-fit:contain;width:100%;height:auto;padding:24px 34px;display:block}.species-empty-state{color:var(--text-muted);font-size:var(--type-p3-size);margin:0;padding:32px}.structure-attribution-screen{color:var(--dioscor-ink)}.attribution-title-row{justify-content:space-between;align-items:center;gap:20px;margin-bottom:30px;display:flex}.summary-panel .attribution-title-row h1{margin:0}.attribution-colour-key{font-size:var(--type-table-head-size);font-weight:var(--font-weight-heavy);white-space:nowrap;flex-wrap:wrap;justify-content:flex-end;align-items:center;gap:7px;display:flex}.attribution-key-pill{border-radius:3px;padding:4px 7px}.attribution-key-pill--high{background:var(--status-active-soft);color:var(--dioscor-high)}.attribution-key-pill--moderate{background:var(--status-warning-soft);color:var(--dioscor-moderate)}.attribution-key-pill--low{background:var(--status-inactive-soft);color:var(--dioscor-low)}.attribution-card-grid{grid-template-columns:repeat(2,minmax(0,1fr));gap:20px;display:grid}.attribution-image-card,.attribution-section{border:1px solid var(--dioscor-border);background:var(--dioscor-page);border-radius:5px;overflow:hidden;box-shadow:0 2px 4px #00000040}.attribution-image-card>header,.attribution-section>header{background:var(--surface-muted);align-items:center;min-height:30px;padding:0 17px;display:flex}.attribution-image-card h2,.attribution-section h2{color:var(--dioscor-ink);font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);margin:0}.attribution-image-stage{background:var(--surface);justify-content:center;align-items:center;min-height:258px;padding:16px;display:flex}.attribution-image-stage span{color:var(--text-danger);font-size:var(--type-p4-size);text-align:center}.attribution-image{object-fit:contain;width:auto;max-width:100%;height:auto;max-height:258px;display:block}.attribution-image-card p{border:1px solid var(--dioscor-border);min-height:31px;color:var(--dioscor-ink);font-size:var(--type-table-head-size);font-weight:var(--font-weight-heavy);border-radius:4px;align-items:center;margin:0 15px 15px;padding:0 12px;display:flex}.attribution-section{margin-top:25px}.attribution-empty-state,.integrated-gradients-copy{color:var(--dioscor-ink);font-size:var(--type-p3-size);margin:0;padding:23px 17px;line-height:1.3}.attribution-empty-state{color:var(--text-muted)}.integrated-gradients-copy strong{color:var(--dioscor-action-blue)}.mechanism-screen,.woe-screen{color:var(--dioscor-ink)}.mechanism-section,.woe-section{border:1px solid var(--dioscor-border);background:var(--dioscor-page);border-radius:5px;margin-top:25px;overflow:hidden;box-shadow:0 2px 4px #00000040}.mechanism-section:first-of-type,.woe-section:first-of-type{margin-top:0}.mechanism-section>header,.woe-section>header{background:var(--surface-muted);align-items:center;min-height:30px;padding:0 17px;display:flex}.mechanism-section h2,.woe-section h2{color:var(--dioscor-ink);font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);line-height:var(--type-p4-line-height);margin:0}.woe-export-title{color:var(--dioscor-ink);font-size:var(--type-h1-size);font-weight:var(--font-weight-semibold);line-height:var(--type-h1-line-height);margin:0 0 24px}.woe-pdf-support-group{background:var(--dioscor-panel-soft);gap:25px;display:grid}.woe-pdf-support-group .woe-section{margin-top:0}.mechanism-card-grid{grid-template-columns:repeat(3,minmax(0,1fr));gap:18px;padding:24px 24px 18px;display:grid}.mechanism-biomarker-card{border:1px solid var(--dioscor-border);background:var(--dioscor-field);text-align:center;border-radius:5px;justify-items:center;min-height:126px;padding:18px 16px;display:grid}.mechanism-biomarker-card h3{color:var(--dioscor-ink);font-size:var(--type-p3-size);font-weight:var(--font-weight-heavy);line-height:var(--type-p3-line-height);margin:0 0 14px}.mechanism-status{min-width:72px;min-height:20px;font-size:var(--type-table-head-size);font-weight:var(--font-weight-heavy);border-radius:3px;justify-content:center;align-items:center;padding:3px 8px;line-height:1;display:inline-flex}.mechanism-status--active{background:var(--status-active-soft);color:var(--dioscor-high)}.mechanism-status--inactive{background:var(--status-inactive-soft);color:var(--dioscor-low)}.mechanism-status--unavailable{background:var(--status-unavailable-soft);color:var(--text-muted)}.mechanism-card-meter{background:var(--surface-meter);border-radius:999px;width:min(196px,100%);height:5px;margin:6px 0 0;overflow:hidden}.mechanism-card-meter span{border-radius:inherit;background:var(--confidence-color,var(--confidence-unavailable));height:100%;display:block}.mechanism-confidence-label{width:min(196px,100%);color:var(--dioscor-ink);font-size:var(--type-p4-size);font-weight:var(--font-weight-medium);text-align:left;justify-self:center;margin-top:12px}.mechanism-confidence-value{color:var(--confidence-color,var(--confidence-unavailable))}.mechanism-pattern-copy{color:var(--dioscor-ink);font-size:var(--type-p3-size);line-height:var(--type-p3-line-height);grid-column:1/-1;margin:3px 0 0}.mechanism-pattern-copy strong{font-weight:var(--font-weight-heavy)}.mechanism-pattern-panels{gap:22px;padding:24px;display:grid}.mechanism-pattern-grid{grid-template-columns:repeat(2,minmax(0,1fr));gap:22px;display:grid}.mechanism-pattern-grid--support{align-items:start}.mechanism-pattern-panel{border:1px solid var(--dioscor-border);background:var(--dioscor-field);border-radius:5px;min-height:294px;padding:14px 18px 18px}.mechanism-pattern-panel h3{color:var(--dioscor-ink);font-size:var(--type-p3-size);font-weight:var(--font-weight-heavy);line-height:var(--type-p3-line-height);margin:0 0 12px}.mechanism-pattern-panel .mechanism-status{box-shadow:none;border:0;border-radius:0;padding-inline:0;background:0 0!important}.mechanism-pattern-panel .mechanism-status--active,.mechanism-pattern-panel .mechanism-status--inactive,.mechanism-pattern-panel .mechanism-status--unavailable{background:0 0!important}.mechanism-pattern-list{margin:0;padding:0;list-style:none;display:grid}.mechanism-pattern-row{border-bottom:1px solid var(--dioscor-border-row);min-height:27px;color:var(--dioscor-ink);font-size:var(--type-p4-size);line-height:var(--type-p4-line-height);grid-template-columns:minmax(112px,1fr) 116px 42px 78px;align-items:center;gap:10px;display:grid}.mechanism-pattern-label{min-width:0}.mechanism-pattern-meter{background:var(--surface-meter);border-radius:999px;height:4px;overflow:hidden}.mechanism-pattern-meter span{border-radius:inherit;background:var(--confidence-color,var(--confidence-unavailable));height:100%;display:block}.mechanism-pattern-confidence{color:var(--confidence-color,var(--dioscor-ink));font-weight:var(--font-weight-heavy);text-align:right}.mechanism-pattern-panel--development{background:var(--surface-muted);text-align:center;align-content:center;min-height:112px;display:grid}.mechanism-pattern-panel--development h3{text-align:left}.mechanism-pattern-panel--development strong,.mechanism-pattern-panel--development p{color:var(--dioscor-ink);font-size:var(--type-p3-size);line-height:var(--type-p3-line-height)}.mechanism-pattern-panel--development strong{font-weight:var(--font-weight-heavy)}.mechanism-pattern-panel--development p{margin:8px 0 0}.mechanism-pattern-panel--compact{grid-template-columns:minmax(0,1fr) auto;align-items:center;min-height:36px;padding-block:10px;display:grid}.mechanism-pattern-panel--compact h3{margin:0}.mechanism-pattern-panel--compact>.mechanism-status,.mechanism-pattern-panel--compact>.mechanism-status--active,.mechanism-pattern-panel--compact>.mechanism-status--inactive,.mechanism-pattern-panel--compact>.mechanism-status--unavailable{box-shadow:none;border:0;border-radius:0;padding-inline:0;background:0 0!important}.mechanism-insights-body{background:var(--surface);padding:18px 17px 20px}.mechanism-table-shell{width:100%;max-width:100%;position:relative;overflow:hidden}.mechanism-table-wrap{background:var(--surface);scrollbar-width:none;width:100%;max-width:100%;padding:0 48px 0 0;overflow-x:auto}.mechanism-table-wrap::-webkit-scrollbar{display:none}.mechanism-table,.woe-reference-table{border-collapse:collapse;width:100%;color:var(--dioscor-ink);font-size:var(--type-p4-size);line-height:var(--type-p4-line-height)}.mechanism-table{table-layout:fixed;min-width:1680px}.mechanism-table-col--biomarker{width:230px}.mechanism-table-col--insight,.mechanism-table-col--enzyme{width:410px}.mechanism-table-col--modifier{width:220px}.mechanism-table-col--pathway,.mechanism-table-col--dose,.mechanism-table-col--evidence{width:180px}.mechanism-table-col--organ{width:110px}.woe-reference-table{table-layout:fixed}.mechanism-table th,.mechanism-table td,.woe-reference-table th,.woe-reference-table td{border:1px solid var(--dioscor-border);text-align:left;vertical-align:top;padding:9px 10px}.mechanism-table thead th,.woe-reference-table thead th{background:var(--surface-table-head);font-size:var(--type-table-head-size);font-weight:var(--font-weight-heavy);text-align:center}.mechanism-table tbody th{width:230px}.mechanism-table tbody tr{height:102px}.mechanism-table tbody th,.mechanism-table tbody td{height:102px;padding:0}.mechanism-table-cell{height:102px;padding:10px;overflow:hidden}.mechanism-table-cell--biomarker{font-weight:var(--font-weight-heavy)}.mechanism-evidence-link{color:var(--dioscor-blue);font:inherit;font-size:var(--type-table-head-size);font-weight:var(--font-weight-heavy);text-align:left;cursor:pointer;background:0 0;border:0;padding:0}.mechanism-evidence-link:focus-visible,.app-dropdown__trigger:focus-visible,.mechanism-scroll-track:focus-visible{border-radius:3px;outline:none;box-shadow:0 0 0 3px #02afef3d}.mechanism-table-arrow{z-index:1;width:34px;height:72px;color:var(--dioscor-blue);cursor:pointer;background:linear-gradient(90deg,#fff0,#fff 55%);border:0;place-items:center;display:grid;position:absolute;top:50%;transform:translateY(-50%)}.mechanism-table-arrow--left{background:linear-gradient(270deg,#fff0,#fff 55%);left:0}.mechanism-table-arrow--right{right:max(0px, calc(100% - (100vw - var(--summary-panel-left-offset,0px) - 42px)))}.mechanism-table-arrow:disabled{opacity:0;pointer-events:none}.mechanism-table-arrow span{border-top:5px solid;border-right:5px solid;width:18px;height:18px;display:block}.mechanism-table-arrow--left span{transform:rotate(225deg)}.mechanism-table-arrow--right span{transform:rotate(45deg)}.mechanism-scroll-track{background:var(--surface-scroll-track);cursor:pointer;touch-action:none;border-radius:999px;height:11px;margin-top:17px;display:block;position:relative;overflow:hidden}.mechanism-scroll-track span{border-radius:inherit;background:linear-gradient(90deg, var(--dioscor-blue), var(--dioscor-purple-bright));height:100%;display:block;position:absolute;top:0}.mechanism-empty-state,.woe-empty-state,.woe-section-note{color:var(--text-muted);font-size:var(--type-p3-size);line-height:var(--type-p3-line-height);margin:0;padding:18px 17px}.woe-section-note{padding-bottom:0}.woe-nearest-list{background:var(--surface);gap:14px;padding:34px 30px 30px;display:grid}.woe-nearest-list__head,.woe-nearest-row{grid-template-columns:42px 78px minmax(0,1.6fr) minmax(0,1fr) 150px;align-items:center;gap:12px;display:grid}.woe-nearest-list__head{border-bottom:1px solid var(--dioscor-border);color:var(--dioscor-ink);font-size:var(--type-p3-size);font-weight:var(--font-weight-heavy);line-height:var(--type-p3-line-height);padding:0 20px 9px}.woe-nearest-list__head span:last-child{text-align:right}.woe-nearest-row{background:var(--surface-table-row-alt);min-height:72px;color:var(--dioscor-ink);font-size:var(--type-p2-size);line-height:var(--type-p2-line-height);border-radius:5px;padding:8px 20px}.woe-nearest-rank{font-weight:var(--font-weight-medium)}.woe-structure-frame{aspect-ratio:1;border:1px solid var(--dioscor-border);background:var(--surface);border-radius:3px;place-items:center;width:76px;display:grid}.woe-structure-image{object-fit:contain;width:100%;height:100%;display:block}.woe-structure-empty{color:var(--text-danger);font-size:var(--type-micro-size);text-align:center;line-height:1.1}.woe-nearest-compound{gap:2px;min-width:0;display:grid}.woe-nearest-compound strong{color:var(--dioscor-ink);font-weight:var(--font-weight-heavy);text-overflow:ellipsis;white-space:nowrap;overflow:hidden}.woe-nearest-compound span{color:var(--dioscor-ink)}.woe-species-list{grid-template-columns:repeat(2,minmax(0,max-content));gap:2px 22px;margin:0;padding:0;list-style-position:inside;display:grid}.woe-species-empty{color:var(--text-muted)}.woe-similarity{gap:8px;min-width:130px;display:grid}.woe-similarity__value{color:var(--woe-similarity-color,var(--dioscor-link-teal));font-size:var(--type-p2-size);font-weight:var(--font-weight-heavy);justify-self:end}.woe-similarity__track{background:var(--surface-track);border-radius:999px;height:7px;overflow:hidden}.woe-similarity__track span{border-radius:inherit;background:var(--woe-similarity-color,var(--dioscor-link-teal));height:100%;display:block}.woe-table-wrap{background:var(--surface);padding:0 16px 22px;overflow-x:visible}.woe-reference-table td{max-width:190px}.woe-section--support{min-height:90px}.woe-support-copy,.woe-known-molecule{color:var(--dioscor-ink);font-size:var(--type-p2-size);line-height:var(--type-p2-line-height);padding:24px 24px 26px}.woe-support-copy{margin:0}.woe-known-molecule{gap:16px;display:grid}.woe-known-molecule>strong{color:var(--dioscor-green);font-size:var(--type-p2-size);font-weight:var(--font-weight-heavy)}.woe-known-molecule__empty{color:var(--text-muted)!important}.woe-known-molecule p{margin:0}.new-compound-flow,.export-flow{z-index:25;place-items:center;display:grid;position:fixed;inset:0}.new-compound-flow__backdrop,.export-flow__backdrop{background:#000000a6;position:absolute;inset:0}.new-compound-modal,.export-flow__card{z-index:1;background:var(--dioscor-panel);width:min(660px,100vw - 32px);min-height:384px;color:var(--dioscor-ink);border-radius:8px;position:relative;box-shadow:0 20px 58px #00000047}.new-compound-modal{box-sizing:border-box;padding-bottom:32px}.new-compound-close,.export-flow__close{background:var(--dioscor-link-teal);width:38px;height:38px;color:var(--on-dark);font-size:var(--type-hidden-size);cursor:pointer;border:0;border-radius:50%;place-items:center;display:grid;position:absolute;top:24px}.new-compound-close{left:24px}.export-flow__close{right:24px}.new-compound-close:before,.export-flow__close:before{content:"×";font-size:var(--type-h1-size);font-weight:var(--font-weight-medium);line-height:1}.new-compound-modal>h2{color:var(--dioscor-ink);font-family:var(--font-display);font-size:var(--type-display-size);font-weight:var(--font-weight-regular);text-align:center;margin:34px 0 0;line-height:1}.new-compound-form{gap:12px;width:min(480px,100% - 72px);margin:42px auto 0;display:grid}.new-compound-form label,.new-compound-form .app-dropdown__label{color:var(--text-strong);font-size:var(--type-h2-size);font-weight:var(--font-weight-medium);line-height:var(--type-h2-line-height)}.new-compound-form input{border:1px solid var(--dioscor-ink);background:var(--dioscor-field);width:100%;height:42px;color:var(--dioscor-ink);font-size:var(--type-control-size);border-radius:5px;padding:8px 18px;line-height:1.2}.new-compound-submit,.export-success-new,.export-success-logout{height:42px;color:var(--on-accent);font-size:var(--type-action-size);font-weight:var(--font-weight-semibold);cursor:pointer;border:0;border-radius:5px;justify-content:center;align-items:center;padding:0 24px;display:inline-flex}.new-compound-submit{background:var(--dioscor-purple);width:138px}.new-compound-disclaimer{border:1px solid var(--dioscor-ink);background:var(--surface-disabled);border-radius:7px;align-items:center;gap:14px;width:min(480px,100% - 72px);min-height:64px;margin:56px auto 0;padding:12px 18px;display:flex}.new-compound-disclaimer p{color:var(--dioscor-ink);font-size:var(--type-h3-size);line-height:var(--type-h3-line-height);margin:0}.new-compound-disclaimer__icon{flex:0 0 36px}.new-compound-loading{min-height:inherit;align-content:start;justify-items:center;display:grid}.new-compound-loading__visual{align-content:start;justify-items:center;width:100%;min-height:312px;display:grid;position:relative}.new-compound-loading__visual h2,.export-flow__card h2{color:var(--text-strong);font-size:var(--type-h2-size);font-weight:var(--font-weight-semibold);line-height:var(--type-h2-line-height);margin-top:34px}.export-flow__card{align-content:start;justify-items:center;display:grid;position:relative}.export-flow__card .loading-spinner{top:54px}.new-compound-loading__visual .loading-spinner+h2,.export-flow__card .loading-spinner+h2{color:var(--dioscor-ink);font-weight:var(--font-weight-medium);margin:188px 0 0}.new-compound-loading__visual .loading-progress,.export-flow__card .loading-progress{width:min(535px,100% - 84px)}.export-success-mark,.export-error-mark{color:var(--dioscor-ink);font-size:var(--type-jumbo-size);font-weight:var(--font-weight-medium);margin-top:64px;line-height:1}.export-error-mark{border:6px solid var(--dioscor-high);width:104px;height:104px;color:var(--dioscor-high);font-size:var(--type-hero-size);border-radius:50%;place-items:center;display:grid}.export-error-copy{width:min(480px,100% - 72px);color:var(--dioscor-ink);font-size:var(--type-p1-size);line-height:var(--type-p1-line-height);text-align:center;margin:18px 0 0}.export-success-actions{gap:18px;margin-top:38px;display:flex}.export-success-new{background:var(--dioscor-action-blue)}.export-success-logout{background:var(--dioscor-green)}.export-success-logout:disabled{cursor:not-allowed;opacity:1}.logout-confirmation{z-index:80;place-items:center;padding:24px;display:grid;position:fixed;inset:0}.logout-confirmation__backdrop{background:#000000a8;position:absolute;inset:0}.logout-confirmation__card{background:var(--dioscor-panel);width:min(728px,100vw - 48px);min-height:556px;color:var(--dioscor-ink);border-radius:10px;justify-items:center;padding:38px 100px 66px;display:grid;position:relative}.logout-confirmation__back{width:52px;height:52px;color:var(--dioscor-ink);cursor:pointer;background:0 0;border:0;border-radius:50%;place-items:center;padding:0;display:grid;position:absolute;top:47px;left:48px}.logout-confirmation__back svg{width:52px;height:52px;display:block}.logout-confirmation__back circle,.logout-confirmation__back path{fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:4px}.logout-confirmation__card h2{color:var(--dioscor-ink);font-family:var(--font-display);font-size:68px;font-weight:var(--font-weight-regular);letter-spacing:0;margin:0;line-height:1}.logout-confirmation__heading{color:var(--mask-solid);font-size:25px;font-weight:var(--font-weight-regular);text-align:center;margin:67px 0 0;line-height:1.2}.logout-confirmation__disclaimer{border:1px solid var(--dioscor-ink);background:var(--surface-disabled);border-radius:9px;align-items:center;gap:22px;width:530px;min-height:136px;margin-top:55px;padding:18px 28px 18px 23px;display:flex}.logout-confirmation__disclaimer svg{flex:0 0 42px;width:42px;height:42px;display:block}.logout-confirmation__disclaimer svg path:first-child{fill:var(--dioscor-ink)}.logout-confirmation__disclaimer svg path:nth-child(2){fill:none;stroke:var(--surface-disabled);stroke-linecap:round;stroke-width:4px}.logout-confirmation__disclaimer svg circle{fill:var(--surface-disabled)}.logout-confirmation__disclaimer p{color:var(--dioscor-ink);font-size:24px;font-weight:var(--font-weight-regular);margin:0;line-height:1.08}.logout-confirmation__actions{grid-template-columns:repeat(2,minmax(0,1fr));gap:26px;width:528px;margin-top:48px;display:grid}.logout-confirmation__export,.logout-confirmation__logout{height:47px;color:var(--on-dark);font-size:var(--type-action-size);font-weight:var(--font-weight-semibold);cursor:pointer;border:0;border-radius:5px;justify-content:center;align-items:center;display:inline-flex}.logout-confirmation__export{background:var(--dioscor-purple)}.logout-confirmation__logout{background:var(--auth-action-green)}.signal-card{border:1px solid var(--dioscor-border);background:var(--dioscor-field);border-radius:5px;min-height:141px;padding:63px 10px 12px;position:relative}.signal-card--interactive{cursor:pointer;transition:background-color .14s,box-shadow .14s}.signal-card--interactive:hover,.signal-card--interactive:focus-visible{background:var(--signal-card-hover)}.signal-card--interactive:focus-visible{outline:none;box-shadow:0 0 0 3px #02afef3d}.signal-icon{justify-content:center;align-items:center;width:50px;height:50px;display:flex;position:absolute;top:8px;left:10px}.signal-icon--dog{width:44px;height:41px;top:10px}.signal-icon--human{width:27px;height:52px;left:22px}.signal-icon--rat-mouse{width:50px;height:44px;top:10px}.signal-icon img{object-fit:contain;width:auto;max-width:100%;height:auto;max-height:100%;display:block}.signal-card h3{color:var(--dioscor-ink);font-size:var(--type-p2-size);font-weight:var(--font-weight-heavy);margin:0}.signal-meter{height:6px;margin-top:3px}.signal-meter__bar{border-radius:5px;height:100%;display:block}.signal-meter__bar--high{background:var(--dioscor-high)}.signal-meter__bar--moderate{background:var(--dioscor-moderate)}.signal-meter__bar--low{background:var(--dioscor-low)}.signal-meter__bar--unavailable{background:var(--confidence-unavailable)}.signal-risk{font-size:var(--type-p4-size);font-weight:var(--font-weight-heavy);margin-top:8px;display:block}.signal-risk--high{color:var(--dioscor-high)}.signal-risk--moderate{color:var(--dioscor-moderate)}.signal-risk--low{color:var(--dioscor-low)}.signal-risk--unavailable{color:var(--text-muted)}.signal-card small{color:var(--dioscor-ink);font-size:var(--type-p4-size);font-weight:var(--font-weight-medium);margin-top:4px;display:block}@media (max-width:1500px){.dioscor-app{overflow-x:hidden}.auth-screen{min-height:100vh;padding:56px 20px 48px}.auth-screen--login,.auth-screen--createAccount,.auth-screen--checkEmail{padding-bottom:48px}.auth-panel{padding:76px min(72px,8vw) 56px}.auth-screen--login .auth-panel,.auth-screen--createAccount .auth-panel,.auth-screen--checkEmail .auth-panel{min-height:auto}.dioscor-screen,.dioscor-screen--summary{width:100%;min-height:100vh;padding:28px 20px 48px}.dioscor-header,.disclaimer-banner,.entry-card,.loading-card,.summary-screen,.summary-top-actions,.summary-meta-row,.summary-divider,.summary-sidebar,.summary-panel{width:100%;position:static;transform:none}.dioscor-header{grid-template-columns:minmax(0,1fr) auto;align-items:center;column-gap:20px;height:auto;margin-bottom:32px;display:grid}.header-logout{grid-area:1/2;position:static}.brand-lockup{flex-wrap:wrap;grid-area:1/1;gap:10px 14px;transform:none}.brand-lockup h1{font-size:clamp(48px,14vw,64px)}.powered-by-lockup{margin-top:10px}.brand-divider{grid-column:1/-1;margin-top:18px;position:static}.disclaimer-banner{max-width:660px;margin:0 auto 28px;padding:14px 18px}.disclaimer-banner p{font-size:var(--type-h3-size)}.entry-card,.loading-card{max-width:720px;height:auto;min-height:408px;margin:0 auto}.loading-card{position:relative;top:auto;left:auto;right:auto}.entry-form{width:min(540px,100%);padding:50px min(90px,8vw);position:static}.entry-input,.app-dropdown--entry-route{--app-dropdown-width:100%;width:100%}.logout-confirmation__card{padding-left:56px;padding-right:56px}.logout-confirmation__disclaimer,.logout-confirmation__actions{width:min(530px,100%)}.loading-spinner,.loading-progress{left:50%}.loading-progress{width:min(535px,100% - 44px)}.summary-top-actions{justify-content:flex-end;margin-bottom:28px}.summary-meta-row{grid-template-columns:repeat(2,minmax(0,1fr));margin-top:28px}.summary-export{grid-column:auto}.snackbar-viewport{width:min(720px,100vw - 32px);bottom:16px}.snackbar{grid-template-columns:40px minmax(0,1fr) auto}.snackbar-content p{white-space:normal}.summary-divider{margin:24px 0}.summary-screen{flex-direction:column;display:flex}.summary-top-actions{order:1}.summary-meta-row{order:2}.summary-divider{order:3}.summary-panel{order:4}.summary-sidebar{order:5;grid-template-columns:1fr;align-items:start;gap:0;margin-top:24px;display:grid}.summary-sidebar>.summary-disclaimer-card{margin:12px 0}.summary-sidebar>.summary-disclosure,.summary-sidebar>.summary-disclaimer-card,.summary-sidebar>.structure-card{grid-area:auto}.summary-disclosure{margin-top:16px}.summary-panel{--summary-panel-left-offset:0px;min-height:0;margin-top:24px;margin-bottom:24px;padding:0 18px 24px}.summary-panel:after{content:none}.summary-tabs{background:var(--dioscor-page);border-radius:0;width:calc(100% + 36px);margin-bottom:33px;margin-left:-18px;margin-right:-18px;position:static;overflow-x:auto}.summary-card-grid,.attribution-card-grid,.mechanism-card-grid,.mechanism-pattern-grid,.summary-result-grid{grid-template-columns:1fr}.mechanism-pattern-row{grid-template-columns:minmax(92px,1fr) 88px 38px 78px}.attribution-title-row{flex-direction:column;align-items:flex-start}.attribution-colour-key{white-space:normal;justify-content:flex-start}}@media (max-width:620px){.auth-screen{padding:30px 14px 40px}.auth-panel{width:100%;padding:52px 22px 38px}.auth-brand h1,.logout-confirmation__card h2{font-size:var(--type-hero-size)}.auth-powered-by{width:168px;height:19px}.auth-form{grid-template-columns:1fr}.auth-form--login,.auth-form--create{row-gap:24px;margin-top:36px}.auth-form-heading h2{font-size:32px}.auth-form-heading p,.auth-helper,.auth-account-switch,.auth-new-account,.auth-expiry-note{font-size:var(--type-p1-size)}.auth-steps{gap:10px}.auth-step{font-size:var(--type-p1-size);gap:8px}.auth-step-index{flex-basis:42px;width:42px;height:42px}.auth-field{font-size:var(--type-control-size);gap:10px}.auth-field--title,.app-dropdown--auth-title{--app-dropdown-width:100%;width:100%}.auth-submit{width:100%}.auth-check-email{gap:22px;margin-top:36px}.auth-email-row{min-height:66px;font-size:var(--type-action-size);padding:12px 14px}.dioscor-screen,.dioscor-screen--summary{padding:24px 14px 40px}.brand-lockup h1{font-size:var(--type-hero-size)}.powered-by-lockup{width:220px;height:25px;margin-top:0}.entry-label,.loading-card h2{font-size:var(--type-control-size)}.entry-form{padding:34px 18px}.summary-top-actions,.summary-meta-row,.summary-sidebar{grid-template-columns:1fr}.summary-screen{flex-direction:column;display:flex}.summary-top-actions{order:1}.summary-meta-row{order:2}.summary-divider{order:3}.summary-panel{order:4;margin-top:0;padding:0 10px 22px}.summary-sidebar{order:5;margin-top:22px}.summary-sidebar>.summary-disclosure,.summary-sidebar>.summary-disclaimer-card,.summary-sidebar>.structure-card{grid-area:auto}.summary-sidebar>.summary-disclaimer-card{margin:12px 0}.summary-top-actions{display:grid}.summary-logout,.summary-new,.summary-export{width:100%}.summary-tabs{scrollbar-width:none;width:calc(100% + 20px);min-height:44px;margin-bottom:24px;margin-left:-10px;margin-right:-10px;padding:0 10px;scroll-padding-inline:10px}.summary-tabs::-webkit-scrollbar{display:none}.summary-tab{height:44px;font-size:var(--type-p1-size);flex:none;padding:10px 12px 0}.species-matrix-toolbar{flex-direction:column;align-items:flex-start;gap:12px;margin-top:18px}.species-subtabs{scrollbar-width:none;order:2;max-width:100%;padding-left:0;overflow-x:auto}.species-subtabs::-webkit-scrollbar{display:none}.species-subtab{min-width:132px;height:44px;font-size:var(--type-p1-size);border-radius:5px 5px 0 0;padding:0 14px}.toxicity-key{flex-wrap:wrap;order:1;margin-bottom:0}.species-table-wrap{padding:18px 12px 20px}.confidence-score-plot{padding:18px 12px;overflow-x:auto}.confidence-axis-headings,.confidence-endpoint-group{min-width:560px}.confidence-axis-headings{margin-left:42px;margin-right:42px}.ld50-plot{padding:18px 12px}.mechanism-insights-body{padding:14px 12px 16px}.mechanism-pattern-panels{scrollbar-width:thin;padding:18px 12px 20px;overflow-x:auto}.mechanism-pattern-grid,.mechanism-pattern-grid--support{min-width:640px}.mechanism-pattern-panel{min-width:0}.mechanism-table-wrap{padding-right:38px}.mechanism-table-arrow{width:30px;height:64px}.mechanism-table-arrow--right{right:0}.woe-nearest-list{padding:20px 12px;overflow-x:visible}.woe-nearest-list__head{display:none}.woe-nearest-row{min-width:0;font-size:var(--type-p3-size);line-height:var(--type-p3-line-height);grid-template-columns:32px 86px minmax(0,1fr);align-items:start;padding:12px}.woe-nearest-compound,.woe-species-list,.woe-similarity{grid-column:3;min-width:0}.woe-structure-frame{width:76px}.woe-species-list{grid-template-columns:1fr;gap:2px}.woe-similarity{width:100%}.woe-similarity__value{justify-self:start}.woe-table-wrap{padding:0 12px 18px;overflow-x:auto}.woe-reference-table{min-width:700px}.logout-confirmation{padding:14px}.logout-confirmation__card{width:100%;min-height:auto;padding:31px 18px 36px}.logout-confirmation__back{width:44px;height:44px;top:24px;left:20px}.logout-confirmation__back svg{width:44px;height:44px}.logout-confirmation__heading{font-size:var(--type-h2-size);margin-top:54px}.logout-confirmation__disclaimer{align-items:flex-start;gap:14px;margin-top:34px;padding:16px}.logout-confirmation__disclaimer p{font-size:var(--type-h3-size);line-height:var(--type-h3-line-height)}.logout-confirmation__actions{grid-template-columns:1fr;gap:14px;margin-top:30px}.metric-pill{justify-content:flex-start}.new-compound-modal>h2{font-size:var(--type-hero-size)}.new-compound-form,.new-compound-disclaimer{width:calc(100% - 36px)}.export-success-actions{width:calc(100% - 48px);display:grid}.export-success-new,.export-success-logout{width:100%}}@media print{body{background:var(--surface)}.skip-link,.summary-top-actions,.summary-export,.snackbar-viewport,.new-compound-flow,.export-flow{display:none!important}.dioscor-app,.dioscor-screen,.dioscor-screen--summary,.summary-screen{background:var(--surface);width:auto;min-height:0;color:var(--dioscor-ink);position:static}.dioscor-header,.summary-meta-row,.summary-divider,.summary-sidebar,.summary-panel{width:auto;position:static}.header-logout{width:100%;margin-top:18px;position:static}.summary-panel{--summary-panel-left-offset:0px;margin-top:24px;padding-top:24px}}.page-shell{width:min(1180px,100% - 32px);margin:0 auto;padding:32px 0 48px}.status-panel h1{margin:0;line-height:1.08}.eyebrow{color:var(--accent-strong);font-size:var(--type-eyebrow-size);font-weight:var(--font-weight-heavy);letter-spacing:0;text-transform:uppercase;margin:0 0 10px}.status-panel{border:1px solid var(--border);border-radius:var(--radius-shell);background:var(--surface);box-shadow:var(--shadow);max-width:720px;margin:80px auto 0;padding:28px}.status-panel--error{border-color:var(--critical-border-soft);background:var(--critical-soft)}.button:focus-visible{border-color:var(--accent);box-shadow:0 0 0 3px color-mix(in srgb, var(--focus) 55%, transparent)}.button{border-radius:var(--radius-control);min-height:42px;font-weight:var(--font-weight-heavy);cursor:pointer;border:1px solid #0000;justify-content:center;align-items:center;padding:10px 14px;text-decoration:none;display:inline-flex}.button:disabled{cursor:wait;opacity:.65}.button--primary{background:var(--accent);color:var(--on-dark)}.button--primary:hover:not(:disabled){background:var(--accent-strong)}@media (max-width:620px){.page-shell{width:min(100% - 20px,1180px);padding-top:20px}}